کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2177240 | 1094632 | 2007 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Hindsight Mediates the Role of Notch in Suppressing Hedgehog Signaling and Cell Proliferation Hindsight Mediates the Role of Notch in Suppressing Hedgehog Signaling and Cell Proliferation](/preview/png/2177240.png)
SummaryTemporal and spatial regulation of proliferation and differentiation by signaling pathways is essential for animal development. Drosophila follicular epithelial cells provide an excellent model system for the study of temporal regulation of cell proliferation. In follicle cells, the Notch pathway stops proliferation and promotes a switch from the mitotic cycle to the endocycle. Here, we show that zinc-finger transcription factor Hindsight mediates the role of Notch in regulating cell differentiation and the switch of cell-cycle programs. Hindsight is required and sufficient to stop proliferation and induce the transition to the endocycle. To do so, it represses string, Cut, and Hedgehog signaling, which promote proliferation during early oogenesis. Hindsight, along with another zinc-finger protein, Tramtrack, downregulates Hedgehog signaling through transcriptional repression of cubitus interruptus. Our studies suggest that Hindsight bridges the two antagonistic pathways, Notch and Hedgehog, in the temporal regulation of follicle-cell proliferation and differentiation.
Journal: - Volume 12, Issue 3, March 2007, Pages 431–442