کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2177349 1094642 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Crosstalk between a Nuclear Receptor and β-Catenin Signaling Decides Cell Fates in the C. elegans Somatic Gonad
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Crosstalk between a Nuclear Receptor and β-Catenin Signaling Decides Cell Fates in the C. elegans Somatic Gonad
چکیده انگلیسی

Summaryβ-Catenin signaling determines the proximal-distal axis of the C. elegans gonad by promoting distal fate in asymmetrically dividing somatic gonad precursor cells (SGPs). Impaired function of the Wnt effector POP-1/TCF, its coactivator SYS-1/β-catenin, and of upstream components including β-catenin WRM-1 causes all SGP daughters to adopt the proximal fate. Consequently, no distal tip cells (DTCs) that would lead differentiation of gonad arms form in the affected hermaphrodites. Here, we show that deficiency of the nuclear receptor NHR-25 has the opposite effect: extra DTCs develop instead of proximal cells. NHR-25 knockdown restores DTC formation and fertility in pop-1 and sys-1 mutants, suggesting that a balance between NHR-25 and β-catenin pathway activities is required to establish both proximal and distal fates. This balance relies on direct crossregulation between NHR-25 and the distinct β-catenin proteins WRM-1 and SYS-1. The nuclear receptor-β-catenin interaction may be an ancient mechanism of cell-fate decision.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 11, Issue 2, August 2006, Pages 203–211
نویسندگان
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