کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2177665 | 1094664 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Rab6 Regulates Transport and Targeting of Exocytotic Carriers Rab6 Regulates Transport and Targeting of Exocytotic Carriers](/preview/png/2177665.png)
SummaryConstitutive exocytosis delivers newly synthesized proteins, lipids, and other molecules from the Golgi apparatus to the cell surface. This process is mediated by vesicles, which bud off the trans-Golgi network, move along cytoskeletal filaments, and fuse with the plasma membrane. Here, we show that the small GTPase Rab6 marks exocytotic vesicles and, together with the microtubule plus-end-directed motor kinesin-1, stimulates their processive microtubule-based transport to the cell periphery. Furthermore, Rab6 directs targeting of secretory vesicles to plasma-membrane sites enriched in the cortical protein ELKS, a known Rab6 binding partner. Our data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space.
Journal: - Volume 13, Issue 2, 7 August 2007, Pages 305–314