کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2177740 | 1094670 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Polarity Determinants Tea1p, Tea4p, and Pom1p Inhibit Division-Septum Assembly at Cell Ends in Fission Yeast Polarity Determinants Tea1p, Tea4p, and Pom1p Inhibit Division-Septum Assembly at Cell Ends in Fission Yeast](/preview/png/2177740.png)
SummaryCorrect positioning of the cell-division plane is crucial for cell function in all organisms. The fission yeast Schizosaccharomyces pombe divides by utilizing an actomyosin-based contractile ring and is an attractive model for the study of cytokinesis. The metazoan anillin-related protein Mid1p stimulates medial assembly of the division septum by recruiting actomyosin-ring components to the medial cortex. Here, we describe an inhibitory mechanism, involving the cell-end-localized polarity determinants Tea1p, Tea4p/Wsh3p, and Pom1p (tip complex), which prevents division-septum assembly at the cell ends. While Mid1p and the tip complex are dispensable for cell viability, their simultaneous loss leads to lethality. The FER/CIP homology protein Cdc15p, which organizes the actomyosin ring and cell membranes during cytokinesis, is a candidate for regulation by the tip complex. Since dual regulation of division-site placement is also seen in nematodes, such regulation might be a general feature of eukaryotic cytokinesis.
Journal: - Volume 12, Issue 6, 5 June 2007, Pages 987–996