کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2177894 1094692 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Spätzle-Processing Enzyme Required for Toll Signaling Activation in Drosophila Innate Immunity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
A Spätzle-Processing Enzyme Required for Toll Signaling Activation in Drosophila Innate Immunity
چکیده انگلیسی

SummaryThe Toll receptor was originally identified as an indispensable molecule for Drosophila embryonic development and subsequently as an essential component of innate immunity from insects to humans. Although in Drosophila the Easter protease processes the pro-Spätzle protein to generate the Toll ligand during development, the identification of the protease responsible for pro-Spätzle processing during the immune response has remained elusive for a decade. Here, we report a protease, called Spätzle-processing enzyme (SPE), required for Toll-dependent antimicrobial response. Flies with reduced SPE expression show no noticeable pro-Spätzle processing and become highly susceptible to microbial infection. Furthermore, activated SPE can rescue ventral and lateral development in embryos lacking Easter, showing the functional homology between SPE and Easter. These results imply that a single ligand/receptor-mediated signaling event can be utilized for different biological processes, such as immunity and development, by recruiting similar ligand-processing proteases with distinct activation modes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 10, Issue 1, January 2006, Pages 45–55
نویسندگان
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