کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2178617 | 1549710 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activity modulation of the bacterial Rho GAP YopE: An inspiration for the investigation of mammalian Rho GAPs
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Activity modulation of the bacterial Rho GAP YopE: An inspiration for the investigation of mammalian Rho GAPs Activity modulation of the bacterial Rho GAP YopE: An inspiration for the investigation of mammalian Rho GAPs](/preview/png/2178617.png)
چکیده انگلیسی
The Yersinia enterocolitica Rho GTPase Activating Protein (Rho GAP) YopE belongs to a group of bacterial virulence factors that is translocated into infected target cells by a type three secretion system. Structurally and biochemically YopE resembles eukaryotic Rho GAPs which control various cellular functions by modulating the activity of Rho GTP binding proteins. Here we summarise the published information on cellular effects, Rho protein substrates, compartmentalisation and turnover of YopE. A fascinating picture evolves of how this virulence factor integrates in host cellular regulatory mechanisms to fine tune bacterial pathogenicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cell Biology - Volume 90, Issue 11, November 2011, Pages 951–954
Journal: European Journal of Cell Biology - Volume 90, Issue 11, November 2011, Pages 951–954
نویسندگان
Martin Aepfelbacher, Bernhard Roppenser, Moritz Hentschke, Klaus Ruckdeschel,