کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2178849 1549729 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A convenient synthesis of nucleoside diphosphate glycopyranoses and other polyphosphorylated bioconjugates
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
A convenient synthesis of nucleoside diphosphate glycopyranoses and other polyphosphorylated bioconjugates
چکیده انگلیسی

In this review, we summarize results obtained using a conceptionally new chemical synthesis of NDP-sugars based on cycloSaligenyl (cycloSal) nucleotides as starting material (cycloSal technique). The cycloSal technique not only leads to stereoisomerically defined NDP-sugars in high yield, but the same principle provides very efficient routes towards nucleoside di- and -triphosphates. Moreover, sugar-nucleotides such as CMP-Neu5Ac and dinucleoside polyphosphates are available. Thus, the method offers a nearly universal chemical access towards a large number of highly interesting bioconjugates and biomolecules.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cell Biology - Volume 89, Issue 1, January 2010, Pages 63–75
نویسندگان
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