کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2181312 | 1095288 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional characterization of the Aspergillus nidulans methionine sulfoxide reductases (msrA and msrB)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Functional characterization of the Aspergillus nidulans methionine sulfoxide reductases (msrA and msrB) Functional characterization of the Aspergillus nidulans methionine sulfoxide reductases (msrA and msrB)](/preview/png/2181312.png)
چکیده انگلیسی
Proteins are subject to modification by reactive oxygen species (ROS), and oxidation of specific amino acid residues can impair their biological function, leading to an alteration in cellular homeostasis. Sulfur-containing amino acids as methionine are the most vulnerable to oxidation by ROS, resulting in the formation of methionine sulfoxide [Met(O)] residues. This modification can be repaired by methionine sulfoxide reductases (Msr). Two distinct classes of these enzymes, MsrA and MsrB, which selectively reduce the two methionine sulfoxide epimers, methionine-S-sulfoxide and methionine-R-sulfoxide, respectively, are found in virtually all organisms. Here, we describe the homologs of methionine sulfoxide reductases, msrA and msrB, in the filamentous fungus Aspergillus nidulans. Both single and double inactivation mutants were viable, but more sensitive to oxidative stress agents as hydrogen peroxide, paraquat, and ultraviolet light. These strains also accumulated more carbonylated proteins when exposed to hydrogen peroxide indicating that MsrA and MsrB are active players in the protection of the cellular proteins from oxidative stress damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fungal Genetics and Biology - Volume 46, Issue 5, May 2009, Pages 410-417
Journal: Fungal Genetics and Biology - Volume 46, Issue 5, May 2009, Pages 410-417
نویسندگان
Frederico Marianetti Soriani, Marcia Regina Kress, Paula Fagundes de Gouvêa, Iran Malavazi, Marcela Savoldi, Andreas Gallmetzer, Joseph Strauss, Maria Helena S. Goldman, Gustavo Henrique Goldman,