کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2181324 1095289 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genomic polymorphism in the population of Candida glabrata: Gene copy-number variation and chromosomal translocations
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Genomic polymorphism in the population of Candida glabrata: Gene copy-number variation and chromosomal translocations
چکیده انگلیسی

The genomic sequence of the type strain of the opportunist human pathogen Candida glabrata (CBS138, ATCC 2001) is available since 2004. This allows the analysis of genomic structure of other strains by comparative genomic hybridization. We present here the molecular analysis of a collection of 183 C. glabrata strains isolated from patients hospitalized in France and around the world. We show that the mechanisms of microevolution within this asexual species include rare reciprocal chromosomal translocations and recombination within tandem arrays of repeated genes, and that these account for the frequent size heterogeneity between chromosomes across strains. Gene tandems often encode cell wall proteins suggesting a possible role in adaptation to the environment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fungal Genetics and Biology - Volume 46, Issue 3, March 2009, Pages 264–276
نویسندگان
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