کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2181445 | 1095296 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Loss and fragmentation of chromosome 5 are major events linked to the adaptation of rad52-ΔΔ strains of Candida albicans to sorbose Loss and fragmentation of chromosome 5 are major events linked to the adaptation of rad52-ΔΔ strains of Candida albicans to sorbose](/preview/png/2181445.png)
Candida albicans can adapt and grow on sorbose plates by losing one copy of Chr5. Since rad52 mutants of Saccharomyces cerevisiae lose chromosomes at a high rate, we have investigated the ability of C. albicans rad52 to adapt to sorbose. Carad52-ΔΔ mutants generate Sou+ strains earlier than wild-type but the final yield is lower, probably because they die at a higher rate in sorbose. As other strains of C. albicans, CAF2 and rad52-ΔΔ derivatives generate Sou+ strains by a loss of one copy of Chr5 about 75% of the time. In addition, rad52 strains were able to produce Sou+ strains by a fragmentation/deletion event in one copy of Chr5, consisting of loss of a region adjacent to the right telomere. Finally, both CAF2 and rad52-ΔΔ produced Sou+ strains with two apparent full copies of Chr5, suggesting that additional genomic changes may also regulate adaptation to sorbose.
Journal: Fungal Genetics and Biology - Volume 44, Issue 8, August 2007, Pages 789–798