کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2181680 1095318 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Two Aspergillus nidulans genes encoding methylenetetrahydrofolate reductases are up-regulated by homocysteine
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Two Aspergillus nidulans genes encoding methylenetetrahydrofolate reductases are up-regulated by homocysteine
چکیده انگلیسی

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate in the synthesis of methionine from homocysteine. We have cloned and characterized two Aspergillus nidulans genes encoding MTHFRs: metA and metF. Mutations in either gene result in methionine requirement; the metA-encoded enzyme is responsible for only 10–15% of total MTHFR activity. These two enzymes belong to different classes of MTHFRs. Mutations in metA but not in the metF gene are suppressed by mutations resulting in enhancement of homocysteine synthesis. The expression of both genes is up-regulated by homocysteine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fungal Genetics and Biology - Volume 44, Issue 7, July 2007, Pages 691–700
نویسندگان
, , , , ,