کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2181714 | 1095324 | 2007 | 11 صفحه PDF | دانلود رایگان |
In fungi, chitin synthases have been classified into five classes according to differences in regions of high sequence conservation. The current investigation was initiated to examine the causes for the polymorphism patterns found in a class II chitin synthase gene (chs2) of Paracoccidioides brasiliensis, in an attempt to determine the evolutionary forces affecting the chitin synthesis metabolic pathway. Neutrality tests were applied to the chs2 sequences exhibited by P. brasiliensis species complex. According to these tests and based on non-synonymous differences, P. brasiliensis data rejected the null hypothesis for a pure drift mutational process owing to a large excess of unique polymorphisms. In contrast, the synonymous and intron site differences did not reject the null hypothesis. This pattern appears consistent with weak selection against most amino acid changes, in which the effect of background selection was not detectable at synonymous nor at intron sites.
Journal: Fungal Genetics and Biology - Volume 44, Issue 5, May 2007, Pages 357–367