کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2181714 1095324 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Background selection at the chitin synthase II (chs2) locus in Paracoccidioides brasiliensis species complex
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Background selection at the chitin synthase II (chs2) locus in Paracoccidioides brasiliensis species complex
چکیده انگلیسی

In fungi, chitin synthases have been classified into five classes according to differences in regions of high sequence conservation. The current investigation was initiated to examine the causes for the polymorphism patterns found in a class II chitin synthase gene (chs2) of Paracoccidioides brasiliensis, in an attempt to determine the evolutionary forces affecting the chitin synthesis metabolic pathway. Neutrality tests were applied to the chs2 sequences exhibited by P. brasiliensis species complex. According to these tests and based on non-synonymous differences, P. brasiliensis data rejected the null hypothesis for a pure drift mutational process owing to a large excess of unique polymorphisms. In contrast, the synonymous and intron site differences did not reject the null hypothesis. This pattern appears consistent with weak selection against most amino acid changes, in which the effect of background selection was not detectable at synonymous nor at intron sites.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fungal Genetics and Biology - Volume 44, Issue 5, May 2007, Pages 357–367
نویسندگان
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