کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2182015 1095435 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development
چکیده انگلیسی

Gadd45 proteins have been implicated in the cellular response to physiological or environmental stress and the accompanying cell cycle arrest, DNA repair, cell survival and senescence or apoptosis. Although their molecular function is well studied, the expression and role of Gadd45 genes during embryonic development in mice is largely unknown. Here we provide a comprehensive comparison of Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development. In situ hybridizations on sectioned and whole mouse embryos show most prominent Gadd45a expression in the tip of the closing neural tube, the cranial and dorsal root ganglia and the somites. Mouse Gadd45b is expressed strongly in the chorion, but only weakly in the embryo proper, including somites and limb buds. Murine Gadd45g expression strongly resembles Xenopus and medaka fish expression in primary neuron precursors and post-mitotic neurons, indicating a conserved role for Gadd45g in vertebrate neurogenesis. Additionally, Gadd45 genes show conserved expression during somitogenesis. In summary, Gadd45 genes are expressed in evolutionary conserved, but also divergent domains, which predominantly encompass areas of cell differentiation, consistent with their established function in growth arrest and DNA demethylation.


► Gadd45a, Gadd45b and Gadd45g expression pattern during mouse embryogenesis.
► Gadd45a expression in the closing neural tube, the ganglia and the somites.
► Gadd45b expression in the chorion, weakly in the somites and limb buds.
► Gadd45g expression in central nervous system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 11, Issue 8, December 2011, Pages 465–470
نویسندگان
, , ,