کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2182023 | 1095435 | 2011 | 8 صفحه PDF | دانلود رایگان |
Nolz-1/Zfp503, a zinc finger-containing gene, is a mammalian member of the SP1-related nocA/elb/tlp-1 gene family. Previous studies have shown that Nolz-1 homologs are important for patterning the rhombomeres in zebrafish hindbrain. We therefore studied the expression pattern of Nolz-1 in the developing mouse hindbrain. Nolz-1 mRNA expression was detected in the prospective rhombomere 3, 5 and caudal regions as early as E8.75. After E11.5, Nolz-1-positive cells were organized as distinct cell clusters, and they were largely non-overlapped with either Pax2-positive or Phox2b-positive domains. Most interestingly, we found that Nolz-1 was specifically expressed by Phox2b-negative/Isl1/2-positive somatic motor neurons, but not by Phox2b-positive/Isl1/2-positive branchial and visceral motor neurons, suggesting that Nolz-1 may regulate development of somatic motor neurons in the hindbrain. In addition to be expressed in differentiating post-mitotic neurons, Nolz-1 was also expressed by progenitor cells in the ventricular zone located in the dorsal part of aqueduct and the alar plates of hindbrain, which suggests a regulatory role of Nolz-1 in the germinal zone. Taken together, based on its domain- and cell type-selective pattern, Nolz-1 may involve in regulation of various developmental processes, including regional patterning and cell-type specification and differentiation in the developing mouse hindbrain.
► Nolz-1/Zfp503 is a mammalian member of the SP1-related nocA/elb/tlp-1 gene family.
► Nolz-1 expression was detected in the prospective rhombomere 3, 5 and caudal regions of hindbrain.
► Nolz-1 was specifically expressed by Phox2b(−)/Isl1/2(+) somatic motor neurons.
► Nolz-1 was not expressed by Phox2b(+)/Isl1/2(+) branchial and visceral motor neurons.
► Nolz-1 may regulate development of somatic motor neurons in developing hindbrain.
Journal: Gene Expression Patterns - Volume 11, Issue 8, December 2011, Pages 525–532