کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2182394 1550067 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Irxl1, a divergent Iroquois homeobox family transcription factor gene
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Irxl1, a divergent Iroquois homeobox family transcription factor gene
چکیده انگلیسی

Iroquois homeodomain (Irx) transcription factors are encoded by a conserved family of six genes that are found in two clusters of three genes each. Irx proteins are highly conserved, and their expression patterns overlap considerably during embryonic development, suggesting genetically redundant functions. We have identified a highly divergent Irx gene, which we term Iroquois homeobox-like 1 (Irxl1). The chromosomal location of Irxl1 is distinct from the Irx gene clusters. Irxl1 is conserved in most vertebrates, and the deduced amino acid sequence of its protein product predicts a homeodomain that bears significant homology to Irx homeodomains, but is clearly very divergent. We also identified in Irxl1 a divergent Iro box, a motif that is the defining feature of the Irx family. Expression of Irxl1 during mouse embryogenesis was distinct from that of most Irx genes, and was largely restricted to the epaxial and hypaxial components of the somites, limb buds, otic vescicle, craniofacial mesenchyme, retinal ganglion cell layer, and lens. We conclude that Irxl1 is a newly identified highly divergent member of the Irx gene family with specific expression patterns in mouse embryogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 7, Issues 1–2, January 2007, Pages 51–56
نویسندگان
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