کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2182470 1550066 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
uPARAP expression during murine lung development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
uPARAP expression during murine lung development
چکیده انگلیسی

Lung remodeling requires active collagen deposition and degradation. Urokinase plasminogen activator receptor-associated protein (uPARAP), or Endo 180, is a cell-surface receptor for collagens, which leads to collagen internalization and degradation. Thus, uPARAP-mediated collagen degradation is an additional pathway for matrix remodeling in addition to matrix remodeling mediated by matrix metalloproteinases and cathepsins. Using immunohistochemistry, we demonstrate extensive uPARAP expression in the mesenchyme throughout murine lung development. By immunofluorescence, we demonstrate significant overlap of uPARAP expression with collagen IV expression, but minimal overlap with collagen I expression in the developing murine lung. Finally, we compared lung development between wild-type and uPARAP−/− mice, and found no significant histologic differences, indicating the presence of alternative collagen degradation pathways during murine lung development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 8, Issues 7–8, September 2008, Pages 486–493
نویسندگان
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