کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2183003 | 1095537 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The influence of intrinsic and extrinsic factors on immune system aging
ترجمه فارسی عنوان
تأثیر عوامل ذاتی و بیرونی بر پیری سیستم ایمنی بدن
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28â and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 219, Issue 6, June 2014, Pages 482-485
Journal: Immunobiology - Volume 219, Issue 6, June 2014, Pages 482-485
نویسندگان
Michael Badowski, Christopher L. Shultz, Yvette Eason, Nafees Ahmad, David T. Harris,