کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2183916 1550302 2008 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families
چکیده انگلیسی

Vertebrates have evolved complex immune specificity repertoires beyond the primordial components found in lower multi-cellular organisms to combat microbial infections. The type II interferon (IFN-γ) pathway represents one such system, bridging innate and acquired immunity and providing host protection in a cell-autonomous manner. Recent large-scale transcriptome analyses of IFN-γ-dependent gene expression in effector cells such as macrophages have highlighted the prominence of two families of GTPases—p47 IRGs and p65 GBPs—that are now beginning to emerge as major determinants of antimicrobial resistance. Here we discuss the recent clarification of known family members, their cellular biochemistry and host defense functions as a means to understanding the complex innate immune response engendered in higher vertebrates such as humans and mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 212, Issues 9–10, 18 January 2008, Pages 771–784
نویسندگان
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