کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2183943 | 1095604 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of docosahexaenoic acid on macrophage functions of rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Docosahexaenoic acid (DHA) is an omega-3 fatty acid which has been demonstrated to exhibit anti-inflammatory effects. The objective of this study was to determine the effect of DHA on phagocytic and chemotactic activities of peritoneal macrophages obtained from rats. DHA was dissolved in 1 ml of corn oil at dose of 36 mg/kg/day and given via oral gavage for 4 weeks. Control rats received 1 ml/day corn oil as vehicle. At the end of the treatment period, peritoneal macrophages were isolated and chemotactic and phagocytic activities were assayed. Chemotactic and phagocytic activities were reduced in rats fed with DHA. These results demonstrated the effect of DHA in modulating immune activities of rat peritoneal macrophages.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 212, Issue 7, 5 September 2007, Pages 583–587
Journal: Immunobiology - Volume 212, Issue 7, 5 September 2007, Pages 583–587
نویسندگان
Mehmet Bulbul, Ruken Tan, Burcu Gemici, Gülay Hacıoglu, Aysel Agar, V. Nimet Izgut-Uysal,