کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2184565 1095886 2013 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Role of miRNAs in Regulating Gene Expression Networks
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The Role of miRNAs in Regulating Gene Expression Networks
چکیده انگلیسی

MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across species, expressed across cell types, and active against a large proportion of the transcriptome. The sequence-complementary mechanism of miRNA activity exploits combinatorial diversity, a property conducive to network-wide regulation of gene expression, and functional evidence supporting this hypothesized systems-level role has steadily begun to accumulate. The emerging models are exciting and will yield deep insight into the regulatory architecture of biology. However, because of the technical challenges facing the network-based study of miRNAs, many gaps remain. Here, we review mammalian miRNAs by describing recent advances in understanding their molecular activity and network-wide function.

Graphical AbstractFigure optionsDownload high-quality image (107 K)Download as PowerPoint slideHighlights
► Network-level perspective of miRNA activity.
► A summary of the structure of eukaryotic Argonaute.
► A comparison of miRNA function in vitro versus in vivo.
► A description of four miRNA families: miR-290–295, let-7, miR-17–92, and miR-34.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 425, Issue 19, 9 October 2013, Pages 3582–3600
نویسندگان
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