کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2189971 1096230 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alternate Pathways for Folding in the Flavodoxin Fold Family Revealed by a Nucleation-growth Model
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Alternate Pathways for Folding in the Flavodoxin Fold Family Revealed by a Nucleation-growth Model
چکیده انگلیسی

A recent study of experimental results for flavodoxin-like folds suggests that proteins from this family may exhibit a similar, signature pattern of folding intermediates. We study the folding landscapes of three proteins from the flavodoxin family (CheY, apoflavodoxin, and cutinase) using a simple nucleation and growth model that accurately describes both experimental and simulation results for the transition state structure, and the structure of on-pathway and misfolded intermediates for CheY. Although the landscape features of these proteins agree in basic ways with the results of the study, the simulations exhibit a range of folding behaviours consistent with two alternate folding routes corresponding to nucleation and growth from either side of the central β-strand.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 358, Issue 3, 5 May 2006, Pages 646–653
نویسندگان
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