کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2190827 1097821 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
β-Arrestin: A signaling molecule and potential therapeutic target for heart failure
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
β-Arrestin: A signaling molecule and potential therapeutic target for heart failure
چکیده انگلیسی

Currently, some of the most effective treatments for heart failure target GPCRs such as the beta-adrenergic receptors (β1AR and β2AR) and angiotensin II type IA receptors (AT1aR). Ligands for these receptors not only function by blocking the deleterious G-protein mediated pathway leading to heart failure, but also signal via G-protein independent pathways that involve receptor phosphorylation by G-protein receptor kinases (GRKs) leading to recruitment of the multifunctional protein, β-arrestin. Originally thought to play a role in GPCR desensitization and internalization, β-arrestin has recently been shown to mediate signaling independent of classical second messengers in a way that is often protective to the heart. The multi-functionality of β-arrestin makes it an intriguing molecule in the development of the next generation of drugs for cardiac diseases with the potential to simultaneously inhibit deleterious G-protein dependent pathways while activating beneficial β-arrestin mediated signaling. In this review, we explore various facets of β-arrestin signaling and offer a perspective on its potential role as a key signaling molecule in the treatment of heart failure. This article is part of a special issue entitled “Key Signaling Molecules in Hypertrophy and Heart Failure.”

Research Highlights
► β-arrestin is known to mediate GPCR desensitization and trafficking.
► β-arrestin has now been shown to activate signaling independent of signaling.
► β-arrestin mediated signaling is cardioprotective.
► Identifying ligands that trigger β-arrestin signaling may lead to a new generation of drugs to treat heart failure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 51, Issue 4, October 2011, Pages 534–541
نویسندگان
, , ,