کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2192343 1097889 2006 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulating the regulator: NF-κB signaling in heart
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Regulating the regulator: NF-κB signaling in heart
چکیده انگلیسی

The Nuclear Factor-κB (NF-κB) signaling pathway has been linked to several pathologic processes in the myocardium including cardiomyocyte proinflammatory cytokine release, ischemia/reperfusion injury, hypertrophy and apoptosis. However, very little is known about the intracellular mechanisms that govern NF-κB activity in the myocardial cells. Recent advances in our understanding of the regulation of NF-κB signaling in non-myocyte systems suggest that the activity of the NF-κB pathway is tightly regulated by a diversity of stress-activated signaling intermediates through direct post-translational modification of various components of the NF-κB pathway. In this review, we will focus on these recent revelations and their implications not only in cardiac pathologies, but in the development of new therapeutic strategies to manage heart disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 41, Issue 4, October 2006, Pages 580–591
نویسندگان
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