STAMPing at the crossroads of normal physiology and disease states

• STAMP family constitutes structurally similar six transmembrane proteins.
• STAMP2 and STAMP3 have iron reductase activity that plays a key role in their function.
• The STAMPs are all implicated in cancer; however, they are involved in distinct signaling pathways.

The six transmembrane protein of prostate (STAMP) proteins, also known as six transmembrane epithelial antigen of prostate (STEAPs), comprises three members: STAMP1-3. Their expression is regulated by a variety of stimuli, including hormones and cytokines, in varied settings and tissues with important roles in secretion and cell differentiation. In addition, they are implicated in metabolic and inflammatory diseases and cancer. Here, we review the current knowledge on the role of STAMPs in both physiological and pathological states.