کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2195691 1550863 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activins and activin antagonists in the human ovary and ovarian cancer
ترجمه فارسی عنوان
فعالان و آنتاگونیست های فعال در تخمدان های انسانی و سرطان تخمدان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


• We review the role and distribution of activins and antagonists in human ovaries.
• Activin subunits are present in most histological subtypes of ovarian cancer.
• Activin A stimulates or inhibits proliferation in different ovarian cancer cell lines.
• Expression levels of activin antagonists are altered in ovarian cancer.
• These antagonists may contribute to tumour growth by blocking activin signalling.

Activins are members of the transforming growth factor β superfamily that play an important role in controlling cell proliferation and differentiation in many organs including the ovary. It is essential that activin signalling be tightly regulated as imbalances can lead to uncontrolled cell proliferation and cancer. This review describes the expression and function of the activins and their known antagonists in both normal and cancerous human ovaries.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 415, 5 November 2015, Pages 126–132
نویسندگان
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