کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2195825 | 1550870 | 2015 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors](/preview/png/2195825.png)
• SF-1 and LRH-1 are nuclear receptors that belong to the NR5A subclass.
• They bind as monomers to nuclear receptor half-sites.
• They have a critical role in development, physiology and are also implicated in endocrine cancers.
• Recent genome-wide studies have shed light on the mechanisms of transcriptional regulation by NR5A nuclear receptors.
SF-1 and LRH-1 are transcription factors that belong to the NR5A family of nuclear receptors that both have an essential role during development. Recent studies at the genome-wide scale have enabled the characterization of the cistrome and transcriptome regulated by SF-1 and LRH-1 in different cell lines and tissues. Those studies have allowed us to make a significant leap forward in our understanding of the mechanisms of transcriptional regulation of NR5A nuclear receptors in stem cells and cancer.
Journal: Molecular and Cellular Endocrinology - Volume 408, 15 June 2015, Pages 138–144