کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2195981 1550879 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The circadian clock machinery controls adiponectin expression
ترجمه فارسی عنوان
ماشین آلات ساعت دیجیتال، کنترل بیان آدپیونکتین را کنترل می کنند
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


• The circadian clock controls the expression of adiponectin transcription factors.
• Adiponectin expression is regulated directly by the circadian clock.

Adiponectin, an adipokine involved in glucose and lipid metabolism, exhibits a circadian manner of expression. Adiponectin expression is mediated by the helix–loop–helix transcription factor sterol regulatory element binding protein (SREBP)-1c. In this study, we tested whether the circadian clock helix–loop–helix transcription factors CLOCK and BMAL1 regulate adiponectin expression. We found that adiponectin expression is regulated by the clock through the circadian expression of its transcription factor peroxisome proliferator-activated receptor γ (PPARγ) and its co-activator PPARγ co-activator 1α (PGC1α) in mouse white adipose tissue and differentiated adipocytes. In addition, reconstitution of the core clock mechanism and siRNA experiments in cell culture suggest that the clock directly activates the adiponectin promoter and mediates its expression. In summary, adiponectin expression is regulated by the circadian clock and through the circadian expression of its transcription factor PPARγ and its co-activator PGC1α.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 399, 5 January 2015, Pages 284–287
نویسندگان
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