کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2196142 1550904 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Disordered follicle development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Disordered follicle development
چکیده انگلیسی

Alterations of ovarian follicle morphology and function have been well documented in women with PCOS. These include increased numbers of growing preantral follicles, failure of follicle growth beyond the mid-antral stage, evidence of granulosa call degeneration, and theca cell hyperplasia. Functional abnormalities include paradoxical granulosa cell hyperresponsiveness to FSH which is clinically linked to ovarian hyperstimulation during ovulation induction. In addition, there is likely a primary theca cell defect that accounts for the majority of excess androgen production in this disorder.The precise mechanisms responsible for altered follicle function are not completely clear. However, several factors appear to influence normal advancement of follicle development as well as impair ovarian steroidogenesis. These include intra- as well as extraovarian influences that distort normal ovarian growth and disrupt steroid production by follicle cells.


► Polycystic ovary morphology is characterized by increased numbers of growing follicles.
► In PCOS follicle development is arrested at the mid-antral stage.
► Granulosa cell responsiveness to FSH is enhanced in women with PCOS.
► Excess androgen production results from a primary defect of theca cell function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 373, Issues 1–2, 5 July 2013, Pages 51–60
نویسندگان
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