Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver

This review summarizes the emerging role of AMP-activated protein kinase (AMPK) in mediating endocrine regulation of metabolic fluxes in the liver. There are a number of hormones which, when acting on the liver, alter AMPK activation. Here we describe those hormones associated with activation and de-activation of AMPK and the potential mechanisms for changes in AMPK activation state. The actions of these hormones, in many cases, are consistent with downstream effects of AMPK signaling thus strengthening the circumstantial case for AMPK-mediated hormone action. In recent years, genetic mouse models have also been used in an attempt to establish the role of AMPK in hormone-stimulated metabolism in the liver. Few experiments have, however, firmly established a causal relationship between hormone action at the liver and AMPK signaling.

► A number of metabolic regulatory hormones activate or de-activate AMPK in the liver.
► Glucagon receptor signaling increases the AMP/ATP ratio and AMPK activity.
► Adiponectin activates AMPK and promotes an anti-lipogenic, pro-oxidative program.
► AMPK integrates signals from hormone action and those resulting from metabolic state.