Sex steroid synthesis in human skin in situ: The roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin

► Sex steroids are well known to affect various skin functions. ► We examined the local biosyntheses of sex steroids in human skin. ► Aromatase plays important roles in estrogen synthesis and in elastic fiber formation. ► StAR is closely associated with testosterone synthesis and hair growth. ► Aromatase and StAR impact skin homeostasis.