کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2196353 | 1550916 | 2012 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: New insights into the mechanisms of activin action and inhibition New insights into the mechanisms of activin action and inhibition](/preview/png/2196353.png)
Like other members of the transforming growth factor-β (TGF-β) superfamily, activins are synthesised as precursor molecules comprising an N-terminal prodomain and C-terminal mature region. During synthesis, the prodomain interacts non-covalently with mature activin, maintaining the molecule in a conformation competent for dimerisation. Dimeric precursors are cleaved by proprotein convertases and activin is secreted from the cell non-covalently associated with its propeptide. Extracellularly, the propeptide interacts with heparan sulfate proteoglycans to regulate activin localization within tissues. The mature activin dimer exhibits the classic ‘open-hand’ structure of TGF-β ligands with ‘finger-like’ domains projecting outward from the cysteine knot core of the molecule. These finger domains form the binding epitopes for type I and II serine/threonine kinase receptors. Activins ability to access its signalling receptors is regulated by the extracellular binding proteins, follistatin, follistatin-like-3, and by inhibins, which, in the presence of betaglycan, sequester type II receptors.
► Activin is a disulphide-linked dimer exhibiting a classic ‘open-hand’ structure.
► Activin potentiates its bioactivity via interactions with type I and II kinase receptors.
► Follistatin, follistatin-like-3, and inhibin block activin/receptor complex formation.
► The pro-region of the activin precursor (prodomain) modulates activin synthesis and signalling.
► The activin prodomain is an attractive tool for targeted inhibition of activin signalling in vivo.
Journal: Molecular and Cellular Endocrinology - Volume 359, Issues 1–2, 15 August 2012, Pages 2–12