کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2196366 | 1550916 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Diagnostic applications for inhibin and activins Diagnostic applications for inhibin and activins](/preview/png/2196366.png)
Inhibin and activins play major roles as paracrine and autocrine signaling molecules in reproduction and development where the main emphasis has been placed in developing potential diagnostic applications. While a role for activin assays in diagnostics has so far been unfounded, ELISAs specific for the biologically active inhibin A and B dimers, and for free inhibin alpha subunits, alone or in combination have found some specific diagnostic applications. Addition of inhibin A to the triple test for Down syndrome in the second trimester of pregnancy, measurement of total inhibin as a marker of certain forms of ovarian cancer in specific circumstances, and inhibin B for male fertility are useful diagnostics. A review of the evidence so far suggests that other applications for inhibin and activin assays have yet to be confirmed, or translated into reliable tools for clinical practice.
► Diagnostic value of inhibin and activin measurements were evaluated.
► Inhibin A enhances diagnosis of Down syndrome in second trimester pregnancy.
► Total inhibin is a marker of certain forms of ovarian cancer.
► Inhibin B is useful in male infertility.
► Other applications remain unclear.
Journal: Molecular and Cellular Endocrinology - Volume 359, Issues 1–2, 15 August 2012, Pages 121–125