کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2196384 | 1550922 | 2012 | 12 صفحه PDF | دانلود رایگان |
In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na+ channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid ‘non-genomic’ activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.
► Aldosterone-induced signalling cascades (MAPK, PKC).
► Crosstalk between rapid and genomic effects of aldosterone.
► Ion transport targets of rapid responses to aldosterone (ENaC, NHE).
Journal: Molecular and Cellular Endocrinology - Volume 350, Issue 2, 24 March 2012, Pages 223–234