کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2196431 1098820 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene expression profiling in adrenocortical neoplasia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Gene expression profiling in adrenocortical neoplasia
چکیده انگلیسی

Transcriptome studies of adrenocortical tumors have shown clear differences between adenomas and carcinomas and identified two subgroups of carcinomas with different prognoses. This review focuses on how transcriptomes have enriched our knowledge about genes previously identified by classical candidate gene approaches, uncovered novel genes relevant to adrenocortical tumor biology, helped to identify and understand specific pathway alterations, and advanced the overall translational relevance of this field of research.


► Transcriptomes discriminate adrenocortical adenomas and carcinomas.
► Transcriptomes identify two groups of carcinomas with a different prognosis.
► In the group of poor prognosis, transcriptomes identify three subgroups.
► One of the three subgroups shows a p53 inactivation, one a Wnt/βcatenin activation.
► The diagnostic and prognostic information are transferred to clinical practice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 351, Issue 1, 31 March 2012, Pages 111–117
نویسندگان
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