Dysregulation of microRNAs in adrenocortical tumors

MicroRNAs (miRNAs) are short non-coding RNAs that are involved in the epigenetic regulation of cellular processes. Different malignancies are often associated with the deregulation of specific sets of miRNAs. The prognosis of adrenocortical cancers (ACCs) is very poor as compared to adrenocortical adenomas (ACAs), and even within ACCs there are cases with better disease specific survival. An improved understanding of the pathobiology of this disease will therefore be useful in facilitating better management of ACCs as well as distinguishing high risk versus low risk subgroups. One third of coding genes are regulated by miRNAs and therefore changes in miRNA expression may be associated with cancer development and progression. In this review we summarize the current understanding of miRNAs in adrenocortical tumors, and highlight their potential in differentiating between ACCs and ACAs, risk stratification and prognosis.

► Up-regulation of miR-483-5p and down-regulation of miR-195 is prognostic in ACCs.
► miRNA-139-5p is up-regulated in ACCs which tend to recur.
► miR-99a/miR-100 is significantly down-regulated in childhood ACTs.
► miRNAs show promise as useful biomarkers in ACCs.