Circadian regulation of pineal gland rhythmicity

The pineal gland is a neuroendocrine organ of the brain. Its main task is to synthesize and secrete melatonin, a nocturnal hormone with diverse physiological functions. This review will focus on the central and pineal mechanisms in generation of mammalian pineal rhythmicity including melatonin production. In particular, this review covers the following topics: (1) local control of serotonin and melatonin rhythms; (2) neurotransmitters involved in central control of melatonin; (3) plasticity of the neural circuit controlling melatonin production; (4) role of clock genes in melatonin formation; (5) phase control of pineal rhythmicity; (6) impact of light at night on pineal rhythms; and (7) physiological function of the pineal rhythmicity.

► Literatures focused on circadian rhythmicity in the mammalian pineal gland are reviewed.
► Local and central mechanisms of pineal rhythmicity are the focus of the review.
► Studies designed to understand the in vivo mechanisms are emphasized.
► Role of pineal circadian products in mammalian physiology is briefly summarized.