کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2197145 1098869 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diversity and biological significance of sex hormone-binding globulin in fish, an evolutionary perspective
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Diversity and biological significance of sex hormone-binding globulin in fish, an evolutionary perspective
چکیده انگلیسی

In fish, two different genes, shbga and shbgb, exist that encode for very different proteins. Shbga is the ortholog of mammalian Shbg and was found in all investigated teleosts. In contrast, Shbgb is highly divergent and appears to be a salmonid-specific protein. Here, we review existing data on fish Shbga and Shbgb that have been obtained in chondrichthyes and osteichtyes. Even though other significant expression sites exist, existing data indicate that Shbga is mainly expressed in liver and subsequently secreted into the blood as a homodimer. In contrast, Shbgb is mainly expressed in the ovary, probably secreted as a monomer, and could contribute to the regulation of local steroid action. Binding studies indicate a specialization of circulating Shbg during evolution towards the preferential binding of estradiol and testosterone in teleosts. In contrast, specific fish steroids such as 11-oxo-androgens and oocyte maturation-inducing steroids that are crucial for reproduction are poorly bound by either form of Shbg.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 316, Issue 1, 5 March 2010, Pages 66–78
نویسندگان
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