کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2197214 1098873 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
NADPH oxidases and angiotensin II receptor signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
NADPH oxidases and angiotensin II receptor signaling
چکیده انگلیسی

Over the last decade many studies have demonstrated the importance of reactive oxygen species (ROS) production by NADPH oxidases in angiotensin II (Ang II) signaling, as well as a role for ROS in the development of different diseases in which Ang II is a central component. In this review, we summarize the mechanism of activation of NADPH oxidases by Ang II and describe the molecular targets of ROS in Ang II signaling in the vasculature, kidney and brain. We also discuss the effects of genetic manipulation of NADPH oxidase function on the physiology and pathophysiology of the renin–angiotensin system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 302, Issue 2, 29 April 2009, Pages 148–158
نویسندگان
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