کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2197468 | 1098885 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sealing the gap between nuclear DNA damage and longevity
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
SummaryA number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect of the aging process. Here, we review a number of mouse models for progeroid syndromes that are caused by inherited defects in nucleotide excision repair and are characterized by rapid onset of aging symptoms and premature death. We argue that alterations in genome maintenance pathways impact complex physiological processes that may affect the onset of clinically defined age-related pathologies, including cancer as well as pathways that are normally associated with longevity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 299, Issue 1, 5 February 2009, Pages 112–117
Journal: Molecular and Cellular Endocrinology - Volume 299, Issue 1, 5 February 2009, Pages 112–117
نویسندگان
Björn Schumacher, Jan H. Hoeijmakers, George A. Garinis,