کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2197722 1550980 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent advances in the study of genes involved in non-syndromic premature ovarian failure
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Recent advances in the study of genes involved in non-syndromic premature ovarian failure
چکیده انگلیسی

Premature ovarian failure (POF) is a common pathology leading to infertility affecting about 1% of women under 40 years old. In POF patients, the ovarian dysfunction is characterized by the lack of the ovarian response to close a negative feedback loop on the synthesis of pituitary gonadotropins. Although the majority of cases are considered as idiopathic, diverse aetiologies have been associated, including genetic factors. Up to now, the potential genetic causes of non-syndromic POF have been established mainly by genetic linkage analysis of familial cases or by the screening of mutations in candidate genes based on animal models. Here, we review recent advances in the study of candidate genes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 282, Issues 1–2, 30 January 2008, Pages 101–111
نویسندگان
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