کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2197801 1550984 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The emerging role of pituitary tumour transforming gene (PTTG) in endocrine tumourigenesis
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The emerging role of pituitary tumour transforming gene (PTTG) in endocrine tumourigenesis
چکیده انگلیسی

It is now 10 years since PTTG was first cloned and isolated. Perhaps the major story of the intervening decade of work performed by numerous groups around the world is the sheer multifunctionality ascribed to this gene. PTTG has been implicated in mechanisms of gene transactivation, cell transformation, angiogenesis, metabolism, apoptosis, DNA repair, genetic instability and mitotic control, both in endocrine and non-endocrine settings. In the current review, we cast a critical eye over a decade of PTTG research within the field of endocrine neoplasia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 278, Issues 1–2, 15 November 2007, Pages 1–6
نویسندگان
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