کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2198281 1551010 2006 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: Revisiting old hypotheses
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: Revisiting old hypotheses
چکیده انگلیسی

Epithelial ovarian cancer (EOC) is often a lethal disease because in many cases early symptoms go undetected. Although research proceeds apace, as yet there are few reliable and specific biomarkers for the early stages of the disease. EOC is an umbrella label for a highly heterogeneous collection of cancers, which includes tumours of low malignant potential, serous cystadenomas, mucinous and clear cell carcinomas, all of which are likely to arise from a number of epithelial cell types and a variety of progenitor lesions. Many, but not all types of EOC are thought to arise from the cells lining ovarian inclusion cysts. In this review, we discuss the hypotheses that have driven our ideas on epithelial ovarian carcinogenesis and examine the morphological and genetic evidence for pathways to EOC. The emergence of laser-capture microdissection and expression profiling by microarray technologies offers the promise of defining these pathways more accurately, as well as providing us with the tools for earlier diagnosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 247, Issues 1–2, 9 March 2006, Pages 4–21
نویسندگان
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