کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2198449 | 1551143 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD31+ cell transplantation promotes recovery from peripheral neuropathy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Recently, we reported that human peripheral blood (PB)-derived CD31+ cells are highly angiogenic. In this study, we investigated the beneficial effects of CD31+ cells on peripheral neuropathy in mice. CD31+ cells were collected from the peripheral blood using magnetic activated cell sorting. CD31+ cells exhibited higher levels of expression of angiogenic genes on real-time reverse transcriptase polymerase chain reaction. Peripheral neuropathy was induced by crushing the sciatic nerve with a hemostat, and CD31+ cells were then injected intramuscularly along the sciatic nerve. CD31+ cell transplantation restored motor nerve conduction velocity and voltage amplitude and improved motor coordination. In addition, CD31+ cell transplantation significantly improved blood perfusion and increased intraneural vascularity in the sciatic nerve. Whole-mount fluorescent imaging and dot blot analysis showed that CD31+ cells in the nerve possessed high engraftment and anti-apoptotic properties. Additionally, injected CD31+ cells displayed neurovascular tropism and are highly incorporated with vasculature. Angiogenic cytokines were augmented in CD31+-injected nerve tissue, suggesting increased neovascularization. Taken together, these results indicate that CD31+ cells might be a novel therapeutic strategy in the treatment of peripheral neuropathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 62, September 2014, Pages 60-67
Journal: Molecular and Cellular Neuroscience - Volume 62, September 2014, Pages 60-67
نویسندگان
YongNan Li, ZhuoBo Zhang, Han-Soo Kim, Seongho Han, Sung-Whan Kim,