کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2199447 | 1099449 | 2006 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Novel transcription factor zfh-5 is negatively regulated by its own antisense RNA in mouse brain Novel transcription factor zfh-5 is negatively regulated by its own antisense RNA in mouse brain](/preview/png/2199447.png)
Here, we report features of a novel transcription factor zfh-5, which we isolated from the mouse brain; in addition to the mRNA, the antisense strand of zfh-5 is also expressed in the developing brain, in a manner complementary to the expression of zfh-5 mRNA. Although most neurons express zfh-5 mRNA soon after their final mitosis, several types of neurons, such as the pyramidal and granule cells in the hippocampus, express the zfh-5 antisense RNA prior to the mRNA expression. Using gene-targeting approach, we showed that this antisense RNA has a negative regulatory role on the expression of zfh-5 mRNA. These observations suggest that, in specific types of neurons, the expression of zfh-5 is additionally regulated by a mechanism depending on this antisense RNA.
Journal: Molecular and Cellular Neuroscience - Volume 31, Issue 2, February 2006, Pages 273–283