کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2199887 1099627 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent developments in the diagnosis of ectoparasite infections and disease through a better understanding of parasite biology and host responses
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Recent developments in the diagnosis of ectoparasite infections and disease through a better understanding of parasite biology and host responses
چکیده انگلیسی

Some conventional methods of diagnosis of ectoparasite infections can have low sensitivity and/or specificity. In addition, early infestations, sub-clinical and carrier hosts often go un-diagnosed, allowing infestations to spread. This review focuses on the important ectoparasites of human, livestock and companion animals for which improved diagnostic tools are either already in use, or in development. These advances in diagnostic technologies have resulted in improved treatment, control and preventative strategies for many ectoparasitic diseases. Immunodiagnostic methods have had a large impact, with the emergence of highly sensitive and specific enzyme-linked immunosorbent assays (ELISAs) for sarcoptic and psoroptic mange, with further improved tests in development. In the present review, the advantages and limitations of such tests are discussed and the potential for future development explored. The increasing use of molecular tools, for example, PCR and other molecular methods, has improved our understanding of the epidemiology of ectoparasitic diseases, with practical consequences for community-based control programmes. Recently, the identification of specific signalling pathways during the host response to ectoparasites has led to the identification of disease biomarkers which, along with new technologies, such as multiplexed assays and microfluidic platforms, could lead to more cost-effective, rapid and accurate diagnosis of infectious diseases.


► Ectoparasites can be difficult to diagnose by conventional techniques.
► Recent developments in immunodiagnostics have had a large impact eg ELISA.
► Advantages and limitations to recent diagnostics are discussed.
► Increasing use of molecular tools has increased understanding and had practical impact.
► Further new technologies are showing promise towards more accurate, cost effective and rapid diagnosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Probes - Volume 26, Issue 1, February 2012, Pages 47–53
نویسندگان
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