کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2200339 1551282 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain cholinergic alterations in rats subjected to repeated immobilization or forced swim stress on lambda-cyhalothrin exposure
ترجمه فارسی عنوان
تغییرات کولینرژیک مغز در موشهای مورد آزمایش که در معرض تثبیت مکرر یا استرس شنا کردن اجباری بر روی لامبدا سایالوتین قرار دارند
کلمات کلیدی
استرس امولسیون کردن، استرس شنا کردن اجباری، لامبدا سایالوتروین، کمبود کولینرژیک مغزی، اختلال یادگیری
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


• Role of stress in the neurobehavioral toxicity of lambda-cyhalothrin investigated.
• Marginal neurobehavioral changes observed in rats exposed to either stress or LCT.
• Pre-exposure of rats to stress on LCT treatment caused brain cholinergic deficits.
• Stress appears to be an important contributor in LCT induced neurotoxicity.

Role of immobilization stress (IMS), a psychological stressor and forced swim stress (FSS), a physical stressor was investigated on the neurobehavioral toxicity of lambda-cyhalothrin (LCT), a new generation type-II synthetic pyrethroid. Pre-exposure of rats to IMS (15 min/day) or FSS (3 min/day) for 28 days on LCT (3.0 mg/kg body weight, p.o.) treatment for 3 days resulted to decrease spatial learning and memory and muscle strength associated with cholinergic-muscarinic receptors in frontal cortex and hippocampus as compared to those exposed to IMS or FSS or LCT alone. Decrease in acetylcholinesterase activity, protein expression of ChAT and PKC-β1 associated with decreased mRNA expression of CHRM2, AChE and ChAT in frontal cortex and hippocampus was also evident in rats pre-exposed to IMS or FSS on LCT treatment, compared to rats exposed to IMS or FSS or LCT alone. Interestingly, changes both in behavioral and neurochemical endpoints were marginal in rats subjected to IMS or FSS for 28 days or those exposed to LCT for 3 days alone, compared to controls. The results suggest that stress is an important contributor in LCT induced cholinergic deficits.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 93, February 2016, Pages 51–63
نویسندگان
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