کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2200384 1551286 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Resveratrol neuroprotection in stroke and traumatic CNS injury
ترجمه فارسی عنوان
محافظت از عصب رسکوراترول در سکته مغزی و آسیب مغزی آسیب دیده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

Resveratrol, a stilbene formed in many plants in response to various stressors, elicits multiple beneficial effects in vertebrates. Particularly, resveratrol was shown to have therapeutic properties in cancer, atherosclerosis and neurodegeneration. Resveratrol-induced benefits are modulated by multiple synergistic pathways that control oxidative stress, inflammation and cell death. Despite the lack of a definitive mechanism, both in vivo and in vitro studies suggest that resveratrol can induce a neuroprotective state when administered acutely or prior to experimental injury to the CNS. In this review, we discuss the neuroprotective potential of resveratrol in stroke, traumatic brain injury and spinal cord injury, with a focus on the molecular pathways responsible for this protection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 89, October 2015, Pages 75–82
نویسندگان
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