کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2200547 | 1551296 | 2014 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: microRNAs affect BCL-2 family proteins in the setting of cerebral ischemia microRNAs affect BCL-2 family proteins in the setting of cerebral ischemia](/preview/png/2200547.png)
• BCL-2 family regulates cerebral ischemic outcome.
• BCL-2 family regulates ER-mitochondrial crosstalk.
• microRNAs regulate the BCL-2 family.
• miR-29 targets multiple BCL-2 family members.
The BCL-2 family is centrally involved in the mechanism of cell death after cerebral ischemia. It is well known that the proteins of the BCL-2 family are key regulators of apoptosis through controlling mitochondrial outer membrane permeabilization. Recent findings suggest that many BCL-2 family members are also directly involved in controlling transmission of Ca2+ from the endoplasmic reticulum (ER) to mitochondria through a specialization called the mitochondria-associated ER membrane (MAM). Increasing evidence supports the involvement of microRNAs (miRNAs), some of them targeting BCL-2 family proteins, in the regulation of cerebral ischemia. In this mini-review, after highlighting current knowledge about the multiple functions of BCL-2 family proteins and summarizing their relationship to outcome from cerebral ischemia, we focus on the regulation of BCL-2 family proteins by miRNAs, especially miR-29 which targets multiple BCL-2 family proteins.
Journal: Neurochemistry International - Volume 77, November 2014, Pages 2–8