کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2200565 1551301 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of long-term exposure of 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) on neuronal transmitter transport, brain immuno-regulatory systems and progression of experimental periodontitis in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Effects of long-term exposure of 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) on neuronal transmitter transport, brain immuno-regulatory systems and progression of experimental periodontitis in rats
چکیده انگلیسی


• Periodontitis is a tissue destructive condition of the tooth supporting tissues.
• The disease is initiated by colonization of dental pathogenic microorganisms.
• Chemicals affect the brain-controlled immuno-regulatory system and lead to disease.
• Four-weeks exposure to MDMA increases the synaptosomal re-uptake of dopamine in rats.
• MDMA potentiates experimental periodontitis possibly by dopaminergic signaling.

The present study was designed to investigate the effects of long-term exposure (4 weeks) to the widely used narcotic drug and putative neurotoxicant 3,4-methylenedioxymetamphetamine (MDMA; “ecstasy”) on neuronal transmitter transport and progression of experimental periodontitis in male Wistar rats. The rats were exposed to MDMA (10 mg/kg/day i.p.) or saline five days a week for four consecutive weeks. Exposure to MDMA induced a significant reduction in the synaptosomal reuptake of serotonin, while the uptake of dopamine was significantly increased 24 h after the last injection of MDMA. In contrast, the synaptosomal uptake of noradrenaline and the vesicular uptake through the vesicular monoamine transporter 2 were not affected. In the experiments of periodontitis development, ligature-induced periodontitis was induced three days prior to MDMA administration. Compared to controls, MDMA-treated rats developed significantly more periodontitis. In conclusion, our results show that long-term exposure to MDMA affects the serotonergic and dopaminergic transport systems in the rat brain and increased the susceptibility to the psychosomatic ailment periodontitis following disturbances of brain immune-regulatory systems. These results are interesting with respect to recent research showing that changes in neurotransmitter signalling may alter the reactivity of brain-controlled immunoregulatory systems controlling pathogenic microorganisms colonizing mucosal surfaces.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 72, June 2014, Pages 30–36
نویسندگان
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