کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2201215 | 1100005 | 2010 | 6 صفحه PDF | دانلود رایگان |

Viral infections are implicated in the onset and promotion of autoimmunity in genetically predisposed individuals. In this study, immune response patterns to herpes viruses were compared in aquaporin 4 (AQP4) antibody positive central nervous system (CNS) autoimmunity and multiple sclerosis (MS).Serum samples of patients with AQP4 antibody positive CNS autoimmunity (n = 52), relapsing–remitting MS (n = 55) and controls including non-autoimmune neurological disorders and healthy individuals (n = 56) were tested for IgG antibodies to herpes viruses 1–6 (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) using commercial ELISA kits.AQP4 antibody positive CNS autoimmunity cases most frequently had IgG responses to four viruses (38.5%), while presence of antibodies to three herpes viruses was most common in MS and controls (41.8% and 35.7%, respectively). Compared to MS, AQP4 positive cases had a significantly higher CMV seropositivity rate (P = 0.003) and a lower prevalence of EBV antibodies (P = 0.01). The analysis of immunoreactivity of samples above the diagnostic threshold revealed that in AQP4 positive CNS autoimmunity the IgG response to EBV (P < 0.001) and VZV (P < 0.01) was lower than in MS, whereas immununoreactivity to HSV-1 was higher than in controls (P < 0.01).The distinct pattern of seroprevalence and immunoreactivity against herpes viruses in AQP4 positive CNS autoimmunity and MS provide further insights to the pathogenetical heterogeneity. Whether these findings reflect an epi-phenomenon of autoimmune disorders or indicate a disease-specific deregulated virus–host interaction needs to be examined in further studies.
Research highlights▶ Distinct pattern of humoral immune responses to herpes viruses in AQP4 antibody positive CNS autoimmunity and relapsing–remitting MS. ▶ Evidence for a different aetiopathogenesis of the two disorders. ▶ Findings may reflect involvement of herpes virus infection in the pathogenesis, facettes of immune dysregulation or predisposition to autoimmunity.
Journal: Neurochemistry International - Volume 57, Issue 6, November 2010, Pages 662–667