کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2201215 1100005 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aquaporin 4 antibody positive central nervous system autoimmunity and multiple sclerosis are characterized by a distinct profile of antibodies to herpes viruses
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Aquaporin 4 antibody positive central nervous system autoimmunity and multiple sclerosis are characterized by a distinct profile of antibodies to herpes viruses
چکیده انگلیسی

Viral infections are implicated in the onset and promotion of autoimmunity in genetically predisposed individuals. In this study, immune response patterns to herpes viruses were compared in aquaporin 4 (AQP4) antibody positive central nervous system (CNS) autoimmunity and multiple sclerosis (MS).Serum samples of patients with AQP4 antibody positive CNS autoimmunity (n = 52), relapsing–remitting MS (n = 55) and controls including non-autoimmune neurological disorders and healthy individuals (n = 56) were tested for IgG antibodies to herpes viruses 1–6 (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) using commercial ELISA kits.AQP4 antibody positive CNS autoimmunity cases most frequently had IgG responses to four viruses (38.5%), while presence of antibodies to three herpes viruses was most common in MS and controls (41.8% and 35.7%, respectively). Compared to MS, AQP4 positive cases had a significantly higher CMV seropositivity rate (P = 0.003) and a lower prevalence of EBV antibodies (P = 0.01). The analysis of immunoreactivity of samples above the diagnostic threshold revealed that in AQP4 positive CNS autoimmunity the IgG response to EBV (P < 0.001) and VZV (P < 0.01) was lower than in MS, whereas immununoreactivity to HSV-1 was higher than in controls (P < 0.01).The distinct pattern of seroprevalence and immunoreactivity against herpes viruses in AQP4 positive CNS autoimmunity and MS provide further insights to the pathogenetical heterogeneity. Whether these findings reflect an epi-phenomenon of autoimmune disorders or indicate a disease-specific deregulated virus–host interaction needs to be examined in further studies.

Research highlights▶ Distinct pattern of humoral immune responses to herpes viruses in AQP4 antibody positive CNS autoimmunity and relapsing–remitting MS. ▶ Evidence for a different aetiopathogenesis of the two disorders. ▶ Findings may reflect involvement of herpes virus infection in the pathogenesis, facettes of immune dysregulation or predisposition to autoimmunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 57, Issue 6, November 2010, Pages 662–667
نویسندگان
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